Protective Effects of Dietary Supplement Spirulina (Spirulina platensis) against Toxically Impacts of Monosodium Glutamate in Blood and Behavior of Swiss mouse

(1) Background: Well-known monosodium glutamate (E-621, MSG), originally used as a food flavor enhancer, was approved approximately in all countries, but the toxicity versus safety of (MSG) are still unclear due to variable scientific toxicological reports. Moreover, it reported trigger elevated frequencies nausea and headaches humans provide deleterious effects on laboratory animals. The objectives present study were (i) estimate possible toxic additive MSG (ii) ameliorating protective dietary supplement spirulina (Spirulina platensis) biochemical parameters blood damage produced organs Swiss mice after applying supplementary daily dose for 4 weeks. (2) Methods: conducted 20 mature mice, which randomly organized into four groups five mice. treatments (I) control group, fed only animal feed drinking water; group II MSG1, received 1 mL MSG; III MSG0.5, treated with 0.5 (IV) MSGS, (aiming reduce toxicity). (3) Results: At end experiment, demonstrated passiveness regarding behavioral aspects. As we hypothesized, reached similar values no histopathological observations have been found. Altogether, our findings evidenced that leads changes kidneys caused important modifications serum. Noticeably, potential effect Spirulina platensis proved described by using FTIR spectroscopy technique. (4) Conclusions: A diet rich antioxidants other plant-derived bioactive compounds may healthy nutrition, alleviating side some additives.